同位素分析儀-甲醛分析儀-北京世紀朝陽科技發展有限公司

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2021-03-16 14:22:00

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文獻名: Formulation and Characterization of Antithrombin Perfluorocarbon Nanoparticles

 

 

作者 Alexander J. Wilson1, Qingyu Zhou2, Ian Vargas1, Rohun Palekar3, Ryan Grabau1, Hua Pan1, Samuel A. Wickline1

1.The USF Health Heart InstituteUniversity of South FloridaTampaUSA

2.College of PharmacyUniversity of South FloridaTampaUSA

3.Department of Biomedical EngineeringWashington University in St. LouisSt. LouisUSA

 

 

摘要:Thrombin, a major protein involved in the clotting cascade by the conversion of inactive fibrinogen to fibrin, plays a crucial role in the development of thrombosis. Antithrombin nanoparticles enable site-specific anticoagulation without increasing bleeding risk. Here we outline the process of making and the characterization of bivalirudin and d-phenylalanyl-l-prolyl-l-arginyl-chloromethyl ketone (PPACK) nanoparticles. Additionally, the characterization of these nanoparticles, including particle size, zeta potential, and quantification of PPACK/bivalirudin loading, is also described.

 

關鍵詞:Perfluorocarbon nanoparticles; Thrombin; PPACK; Bivalirudin; Anticoagulation 


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同位素分析儀-甲醛分析儀-北京世紀朝陽科技發展有限公司 同位素分析儀-甲醛分析儀-北京世紀朝陽科技發展有限公司
同位素分析儀-甲醛分析儀-北京世紀朝陽科技發展有限公司
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